The important role of 38275-55-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,38275-55-7, its application will become more common.

Application of 38275-55-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 38275-55-7 as follows.

Intermediate 5; l-(5-Fluoropyrimidin-2-yl)ethanoneTo a solution of 5-fluoropyrimidine-2-carbonitrile (Intermediate 4, 2.5 g) in Et2O (50 ml) at 00C was added drop-wise a solution of MeMgBr (12 ml, 3.0M in Et2O). The resulting solution was stirred at this temperature for 30 minutes, and was then allowed to warm to ambient temperature overnight. The mixture was quenched with a solution of saturated NH4Cl(aq) and extracted with Et2O. The organic extracts dried and evaporation gave a colored residue. Purification by column chromatography (ISCO, 3% MeOH/DCM) to afford the title compound (800 mg). 1H NMR (CDCl3) delta 8.75 (s, 2H), 2.77 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,38275-55-7, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/7753; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia