Synthetic Route of 29509-92-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 29509-92-0, name is 4-Chloro-6-methyl-2-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a solution of 2-(4-bromophenyl)-4-chloro-6-methylpyrimidine (8a, 2.27 g) in acetonitrile (20 mL) was added ethanolamine (2.0 mL), and the mixture was stirred at 70 C for 14 h. To the reaction mixture was added additional ethanolamine (4.0 mL) and the mixture was stirred at 85 C for 6.5 h. The reaction mixture was cooled down to room temperature, and evaporated in vacuo. To the resulting residue was added 1 M aqueous sodium hydroxide (40 mL), and extracted with ethyl acetate. The organic layer was dried, and the desiccant was removed by filtration, and then the solvent was evaporated in vacuo. The resulting residue was purified by silica gel column chromatography (chloroform-methanol) to obtain 9a (2.03 g, 82%) as a white amorphous solid.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 29509-92-0, 4-Chloro-6-methyl-2-phenylpyrimidine.
Reference:
Article; Negoro, Kenji; Yonetoku, Yasuhiro; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki; Bioorganic and Medicinal Chemistry; vol. 20; 7; (2012); p. 2369 – 2375;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia