As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H4ClN3
a) 4-iodo-7H-pyrrolo[2,3-d]pyrimidineA mixture of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (336 mg, 2.15 mmol) and 3.5 ml_ of 57% hydriodic acid was stirred at room temperature for 16 hours. The solid was filtered off, suspended in 3 ml_ of water and brought to pH = 8 with aqueous ammonia solution. The suspension was cooled down to 0 5C and the solid was filtered off, washed with cold water and dried to give the desired product (410 mg). The product contains about 10% of the starting material.
With the rapid development of chemical substances, we look forward to future research findings about 3680-69-1.
Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; DRACONIS PHARMA, S.L.; ALMIRALL, S.A.; TORRENS JOVER, Andoni; MERCE VIDAL, Ramon; CALDENTEY FRONTERA, Francesc Xavier; RODRIGUEZ GARRIDO, Antonio, David; CARCELLER GONZALEZ, Elena; SALAS SOLANA, Jordi; WO2013/37960; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
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