Adding a certain compound to certain chemical reactions, such as: 3438-46-8, 4-Methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H6N2, blongs to pyrimidines compound. Formula: C5H6N2
To a solution of compound 4-methylpyrimidine (2.07 g, 22.0 mmol) in THF (150 mL) was added AIBN (0.36 g,2.2 mmol) followed by a solution of NBS (4.7 g, 26 mmol) in THF (20 mL) at 0 C,The reaction was then heated to 70 C overnight. After cooling the reaction mixture was filtered through celite, the filtrate was concentrated under reduced pressure,The crude product was purified by silica gel column chromatography (eluent:PE / EtOAc (v / v) = 3/2) to give 1.5 g of a red-brown oil, yield: 39%.
The synthetic route of 3438-46-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Bai Shun; Zhou Youbo; Yang Tiping; He Wei; Zhang Yingjun; Zheng Changchun; (103 pag.)CN106749268; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia