Electric Literature of 4270-27-3 ,Some common heterocyclic compound, 4270-27-3, molecular formula is C4H3ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
This compound was prepared by the method of Ishikawa et al. as described in Heterocycles 1990, 31 (9), 1641. 4-Chloro-uracil (Lancaster) (23. [36] g, 0.16 mol) was dissolved in dimethyl sulfoxide (100 [ML)] and treated with potassium carbonate [(11.] 2 g, 0.08 mol) and [1-IODOBUTANE] (Aldrich) (52.8 mL, 0.48 mol). After stirring at [23 oC] for 18 h, the reaction was then mixed with water and extracted with ethyl acetate (3X). The combined ethyl acetate layers were then washed with diluted aqueous sodium chloride solution and brine, dried (sodium sulfate) and concentrated to dryness to afford the crude product as an off-white solid (27.34 g, 85 %).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4270-27-3, 6-Chloropyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2003/106459; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia