As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4595-61-3, name is Pyrimidine-5-carboxylic acid, molecular formula is C5H4N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C5H4N2O2
5-Pyrimidinecarboxylic acid (500mg) in thionyl chloride (5mL) was stirred at 110¡ãC5 under nitrogen for 1h. The solvent was evaporated under vacuum to give 5-pyrimidinecarbonyl chloride as a brown oil (505mg). (4-Bromo-2-fluorophenyl)(iodo)zinc intetrahydrofuran (0.5M, 7.0ml_) was added slowly to a stirred mixture of the acid chloride(500mg) and tetrakis(triphenylphosphine)palladium(0) (203mg) in tetrahydrofuran (3mL) atroom temperature under nitrogen then stirred at room temperature for 1h. Aqueous10 ammonium chloride (1M, 5mL) was added and the mixture was absorbed onto silica andpurified by chromatography on a silica column eluting with a cyclohexane/ethyl acetategradient to give the title compound (712mg).LC-MS: Rt 2.65min.
With the rapid development of chemical substances, we look forward to future research findings about 4595-61-3.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/73189; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia