In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4316-93-2, name is 4,6-Dichloro-5-nitropyrimidine, the common compound, a new synthetic route is introduced below. Formula: C4HCl2N3O2
General procedure: To a cooled to 5 C suspension of 4,6-dichloro-5-nitropyrimidine (6) (1.94 g, 10 mmol) and triethylamine (1.01 g, 10 mmol) in dichloromethane (10 mL), the corresponding ethyl N-alkylglycinate (10 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 30 min. The solution was then washed with water, the organic layer dried with Na2SO4 and evaporated under reduced pressure to dryness. The residue was purified by crystallization or column chromatography.
The synthetic route of 4316-93-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jakubkien?, Virginija; Linkus, Vytautas; ?ikotien?, Inga; Arkivoc; vol. 2018; 7; (2018); p. 154 – 171;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia