The important role of 49845-33-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound,49845-33-2, 2,4-Dichloro-5-nitropyrimidine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine, molecular formula is C4HCl2N3O2, molecular weight is 193.9756, as common compound, the synthetic route is as follows.Application In Synthesis of 2,4-Dichloro-5-nitropyrimidine

Example A3 a). Preparation i of intermediate..1.1; A solution of cyclohexanamine (0.062 mol) in iV,JV-dimethylacetamide (20 ml) was added dropwise to a cooled (-100C) solution of 2,4-dichloro-5-nitropyrimidine (0.062 mol) and DIPE (8.1 g) in 7V,7V-dimethylacetamide (80 ml), then the reaction mixture was allowed to reach room temperature overnight, yielding intermediate 11 (contains regio-isomer; used as such in the next reaction steps). EPO

At the same time, in my other blogs, there are other synthetic methods of this type of compound,49845-33-2, 2,4-Dichloro-5-nitropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/74985; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia