Application of 32779-36-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 32779-36-5, name is 5-Bromo-2-chloropyrimidine, molecular formula is C4H2BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Sodium iodide (3.75 g, 25.0 mmol) and a 55 wt% aqueous hydriodic acid solution (1.48 g) were added sequentially to a chloroform solution (8.0 ml) of 5-bromo-2-chloropyrimidine (2.90 g, 15.0 mmol), at 0C, and stirring was carried out at room temperature for 20 hours. After completion of the reaction, the reaction solution was poured into ice water, followed by extraction with ethyl acetate. The extract was washed sequentially with water and saline, and then dried over anhydrous sodium sulfate. The resulting organic layer was concentrated to afford 5-bromo-2-iodopyrimidine (3.00 g) as a colorless amorphous substance. This product was used in the next reaction without purification.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 32779-36-5, 5-Bromo-2-chloropyrimidine.
Reference:
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia