Adding a certain compound to certain chemical reactions, such as: 5305-59-9, 6-Chloropyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 6-Chloropyrimidin-4-amine, blongs to pyrimidines compound. name: 6-Chloropyrimidin-4-amine
6-Chloropyrimidin-4-amine (4.1 g, 31.6 mmo1)was suspended in acetonitrile. DMAP (0.966 g, 7.91 mmo1) anddi-tert-butyl dicarbonate (14.74 g, 67.5 mmo1) were addedand the mixture was stirred at rt for 3 days. The solvent wasevaporated and the residue was purified by silica gel using0-15% ethyl acetate in hexanes to give 6[bis(tert-butoxycarbony1)amino ]-4-ch1oropyrimidine as a white solid (6.27 g,19.01 mmo1,60%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,5305-59-9, 6-Chloropyrimidin-4-amine, and friends who are interested can also refer to it.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, JAMES H; MCDONALD, IVAR M; KING, DALTON; OLSON, RICHARD E; WANG, NENGHUI; IWUAGWU, CHRISTIANA I; ZUSI, F.CHRISTOPHER; MACOR, JOHN E; (330 pag.)JP5714745; (2015); B2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia