Electric Literature of 57489-77-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.57489-77-7, name is 5,7-Dichloropyrazolo[1,5-a]pyrimidine, molecular formula is C6H3Cl2N3, molecular weight is 188.01, as common compound, the synthetic route is as follows.
Step C – Synthesis of 5-chloropyrazolo[ 1 ,5-a]pyrimidin-7-amine (Int-9c)To 5,7-dichloropyrazolo[ 1 ,5-a]pyrimidine (Int-9b, 7.6 g, 40.4 mmol) in a sealed vessel was added NH4OH (100 mL). The vessel was then sealed and heated at 85 0C for 2.5 hours, at which time the consistency of the white solid had changed (from foamy white solid to free-flowing white solid). The vessel was removed from the heat source and allowed to cool to room temperature overnight. On cooling, the contents of the vessel were collected and dried by vacuum filtration giving 5-chloropyrazolo[l,5- a]pyrimidin-7-amine (Int-9c) as a yellow-tinged white solid (6.8 g, 40.3 mmol, 100%).
The chemical industry reduces the impact on the environment during synthesis 57489-77-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; SCHERING CORPORATION; CHENG, Cliff, C.; ZENG, Hongbo; SHIPPS, Jr., Gerald, W.; DENG, Yongqi; MENG, Zhaoyang; ZHAO, Lianyun; NAN, Yang; SUN, Binyuan; LIU, Duan; REDDY, Panduranga, A.; SIDDIQUI, M., Arshad; WO2011/2887; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
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