Reference of 6214-47-7, Adding some certain compound to certain chemical reactions, such as: 6214-47-7, name is Ethyl 2-(4-chloropyrimidin-5-yl)acetate,molecular formula is C8H9ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6214-47-7.
To a nitrogen de-gassed solution of ethyl 2-(4-chloropyrimidin-5-yi)acetate {1108) (0.823 g, 4.10 mmol) in dry DMF (15 mL) were added triethylamine (1.715 mL, 12.31 mmoi) followed by triphenylphosphine (0.124 g, 0.473 mmol), trans- dichlorobis(triphenyl-phosphine)pailadium(ll) (0.144 g, 0.205 mmoi), Cu(l)l (0,078 g, 0.410 mmol) and finally (triethyisilyi)acetylene (1.470 mL, 8.204 mmol). The reaction mixture was then heated under microwave irradiation at 120 C for 25 minutes, concentrated in vacuo and purified by silica gel chromatography (isoiera Biofage, 40 g Si cartridge, 0-30% EtOAc in petroleum benzine 40-60 C) to give the title compound (1109) (1.176 g, 94% yield) as a yellow-orange oil; 1H NMR (400 MHz, CDCI3) delta 9.08 (s, 1 H), 8.68 (s, 1 H), 4.18 (q, J = 7.1 Hz, 2H), 3.80 (s, 2H), 1.26 (t, J = 7.1 Hz, 3H), 1.10 – 1.01 (m, 9H), 0.77 – 0.67 (m, 6H) LCMS Method C: rt 6.64 min; m/z 305.1 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6214-47-7, Ethyl 2-(4-chloropyrimidin-5-yl)acetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner; WO2014/27199; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
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