Adding a certain compound to certain chemical reactions, such as: 6214-65-9, 5-Acetyluracil, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines
Example P41; benzofuro[3,2-d]pyrimidine-2,4(1H,3H)-dione:To a stirred solution of 3-amino-2,3-dihydrobenzofuran-2-carboxamide (82.2 mg, 0.461 mmol, 1.0 eq.) in anhydrous toluene (8 mL) under an inert atmosphere was added oxalyl chloride (70.2 mg, 553 mumol, 1.2 eq.) in a dropwise manner. The resulting mixture was heated to reflux (115 0C) for 4 hours whereupon it was cooled and stirred for a further 16 hours. The crude reaction mixture was concentrated to half of its volume and filtered to give a colorless solid (41.5 mg, 45 %).Analytical data:1H-NMR (400 MHz, DMSO): delta 11.80 (s, 1 H), 8.50-7.20 (m, 4H).13C-NMR (125 MHz, DMSO): delta 162.2, 157.0, 152.7, 134.6, 128.4, 125.9, 125.1 ,123.5, 121.1 , 112.2.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6214-65-9, 5-Acetyluracil, and friends who are interested can also refer to it.
Reference:
Patent; UNIVERSITY OF BASEL; CMILJANOVIC, Vladimir; CMILJANOVIC, Natasa; GIESE, Bernd; WYMANN, Matthias; WO2010/52569; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia