Adding a certain compound to certain chemical reactions, such as: 635698-56-5, tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C12H15Cl2N3O2, blongs to pyrimidines compound. Computed Properties of C12H15Cl2N3O2
To a stirred solution of tert-butyl 2,4-dichloro- 7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate (0.3 g, 0.99 mmol) in i- PrOH (80 ml) were added 3-(aminomethyl)phenol (0.2 g, 1.18 mmol) and TEA (0.3 g, 2.96 mmol). The resulting mixture was stirred at 100 oC for 16 hrs. The reaction mixture was poured into ice-water (50 mL), and then extracted with EtOAc (50 mL x3). The combined organic layer was dried with Na2SO4, and concentrated to give a crude product which was purified by column (3470) chromatography on silica gel (hexane/ethyl acetate) to afford tert-butyl 2-chloro- 4-[(3-hydroxyphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6- carboxylate (0.35 g, 90.8%) as a white solid. LCMS (M+H+) m/z: calcd.391.1; found 391.2.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,635698-56-5, tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; CLEAVE BIOSCIENCES, INC.; ZHOU, Han-Jie; WUSTROW, David; (498 pag.)WO2016/200840; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia