Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 661463-17-8, name is 4-Bromo-6-fluoroquinoline, A new synthetic method of this compound is introduced below., Formula: C9H5BrFN
The compound 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylic acid tert-butyl ester14a (1.64 g, 5.3 mmol), 4-bromo-6-fluoroquinoline (1 g, 4.4 mmol), tetrakis(triphenylphosphine)palladium (508 mg, 0.44 mmol), potassium carbonate (1.22 g, 8.8 mmol), water (2 ml) and 1,4-dioxane (10 ml) were mixed, and then heated in a microwave reactor at 110 C for 30 minutes under a nitrogen atmosphere. After cooling to room temperature, it was filtered, and the filtrate was evaporated under reduced pressure. To give the desired product 4-(6-fluoroquinolin-4-yl)-3,6-dihydropyridine-1(2H)-carboxylic acid tert-butyl ester 14b (2g, crude).This product was used directly in the next step without further purification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.