With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6622-92-0, name is 2,6-Dimethylpyrimidin-4-ol, molecular formula is C6H8N2O, molecular weight is 124.14, as common compound, the synthetic route is as follows.category: pyrimidines
SYNTHESIS EXAMPLE 1 Synthesis of N-(2-methylbenzyl)-2-(2,4-dimethyl-6-pyrimidi-nyloxy)butylamide (Compound No. 96) To 50 ml of acetone were dissolved 2.6 g (0.021 mol) of 2,4-dimethyl-6-hydroxypyrimidine and 5.2 g (0.091 mol) of N-(2-methylbenzyl)-2-bromobutylamide, and then 3.5 g (0.025 mol) of anhydrous potassium carbonate powder was added thereto, followed by heating under reflux with stirring. The reaction solution was poured into water, and the product formed was extracted with ethyl acetate. The ethyl acetate layer was washed successively with dilute caustic soda and water and then dried over glauber’s salt. Subsequently, the solvent was distilled off and the resulting crude crystal was recrystallized from ethanol to give N-(2-methylbenzyl)-2-(2,4-dimethyl-6-pyrimidinyloxy)butylamide with m.p. 156 to 157 C. as a colorless needle crystal, at an yield of 58% relative to N-(2-methylbenzyl)-2-bromobutylamide.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6622-92-0, 2,6-Dimethylpyrimidin-4-ol, and friends who are interested can also refer to it.
Reference:
Patent; Ube Industries, Ltd.; US4747866; (1988); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia