Reference of 6972-27-6 , The common heterocyclic compound, 6972-27-6, name is 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, molecular formula is C6H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound 6 (15 g, 74.5 mmol) was added portionwise to a cooled solution of cone. H2S04 (40 mL) . The reaction temperature was maintained below 10 C. Fuming nitric acid (15 mL) was added dropwise to the above reaction mixture and it was stirred for 2 h at the same temperature. The reaction nixture was poured onto the ice cold water (500 mL) and extracted with chloroform (2×260 mL). The combined organic extracts were washed with water (260 mL), dried over anhydrous Na2S04 and concentrated in vacuo to give the title compound (12.0 g) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta (ppm): 3.07 and 3.26 (both s, both 3H)
The synthetic route of 6972-27-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LATVIAN INSTITUTE OF ORGANIC SYNTHESIS; ARSENJANS, Pavels; VASILJEVA, Jelena; DOMRACHEVA, llona; SHESTAKOVA, Irina; GULBE, Anita; KANEPE-LAPSA, Iveta; KAUSS, Valerjans; KALVINS, Ivars; (33 pag.)WO2016/159747; (2016); A1;,
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