Synthetic Route of 799842-07-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 799842-07-2, name is N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide. This compound has unique chemical properties. The synthetic route is as follows.
The organic layer was concentrated at a temperature in the range of from about 60 C. to about 70 C. under reduced pressure. The white solid obtained was then added to toluene (300 ml) at a temperature of about 25 C. Tri-n-butyl phosphine was then slowly added. After about 20 to about 25 minutes, a bright white solid falls out and is filtered and washed with toluene (100 mL). The solid was then dried in an oven at a temperature below about 50 C. until the moisture content was about 1%. The dried solid appeared as a white crystalline solid weighing about 29 g to about 29.5 g. The yield was about 97% to about 99%, having a mp 180-182 C., and a purity greater than 99% as determined by HPLC. The IR (KBr) spectrum shows the absorption bands at cm-1 2962 (C-H str), 1604 (-CC-str), 1155 (SO2 str). The 1H-NMR (DMSO-d6) shows delta7.8-7.9[dd,2H,Ar-H], 7.4-7.5[t,2H,Ar-H], 4.0[d,2H,CH2P],3.4-3.5 [2×s,6H,NCH3,SO 2CH3], 3.41 [m,1H,CH(CH3)2], 1.9-2.0[t,6H,P-(CH2)],1.10-1.29 [m,18H, -(CH2)3-] 0.81[t,9H,(CH2-CH3)3]. The CI mass shows m/z 538.4 (base peak). The elemental analysis calculated % C 54.36; % H 7.49; % N 6.79; Observed % C 54.30; % H 7.41, % N 6.72.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 799842-07-2, N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide.
Reference:
Patent; Joshi, Narendra; Bhirud, Shekhar Bhaskar; Chandrasekhar, Batchu; Rao, K. Eswara; Damle, Subhash; US2005/124639; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia