Related Products of 89793-12-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89793-12-4, name is Ethyl 2-chloropyrimidine-5-carboxylate, molecular formula is C7H7ClN2O2, molecular weight is 186.6, as common compound, the synthetic route is as follows.
Ethyl 2-chloropyrimidine-5-carboxylate (7.0 Kgs),ethanol (60 Kgs), 2-Chloroaniline (9.5 Kgs, 2 eq) and acetic acid (3.7 Kgs, 1.6 eq) were charged to a reactor under inert atmosphere. The mixture was heated to reflux. After at least 5 hours the reaction was sampled for HPLC analysis (method TM-113.1016). When analysis indicated reaction completion, the mixture was cooled to 70 ± 5 °C and N,N10 Diisopropylethylamine (DIPEA) was added. The reaction was then cooled to 20 ± 5°C andthe mixture was stirred for an additional 2-6 hours. The resulting precipitate is filtered and washed with ethanol (2 x 6 Kgs) and heptane (24 Kgs). The cake is dried under reduced pressure at 50 ± 5 °C to a constant weight to produce 8.4 Kgs compound 11(81percent yield and 99.9percent purity.
Statistics shows that 89793-12-4 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-chloropyrimidine-5-carboxylate.
Reference:
Patent; ACETYLON PHARMACEUTICALS, INC.; VAN DUZER, John, H.; SEYEDI, Farzaneh; LIU, Gui; (100 pag.)WO2016/200919; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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