Reference of 6299-85-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6299-85-0, name is Methyl 2,6-dichloropyrimidine-4-carboxylate. A new synthetic method of this compound is introduced below.
A suspension of methyl 2,6-dichloropyrimidine-4-carboxylate (1g, 4.87 mmol) in methanol (20 ml) was cooled to -20C, to this 2,4-difluoro benzylamine (0.627mg, 4.39 mmol) and triethylamine (0.98 mg, 9.74 mmol) were added. The reaction mixture was stirred at same temperature for 1 hr then at room temperature for 4 hrs. Methanol was removed under vacuum. The residue was purified by column chromatography to get the title compound. Yield: 45.93% TLC: Pet ether/Ethyl acetate (7/3): Rf: 0.4 LCMS: Mass found (+MS, 314.0) Rt (min): 4.16 Area %: 97.75 (at max), 98.54 (at 254nm) HPLC: > 99% Rt (min): 4.23 Area %: 99.27 (at max), 98.66(at 254nm) 1H NMR (400MHz, DMSO-d6): delta 8.79-8.76 (m, 1 H), 7.47-7.41 (m, 1 H), 7.30-7.24 (m, 1 H), 7.12 (s, 1 H), 7.10-7.05 (m, 1 H), 4.71 (d, J = 5.52 Hz, 2H), 3.83 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6299-85-0, its application will become more common.
Reference:
Patent; MERCK PATENT GMBH; HEINRICH, Timo; BRUGGER, Nadia; JOSEPHSON, Kristopher; WO2013/4332; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia