As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10070-92-5, name is Pyrimidine-5-carbaldehyde, molecular formula is C5H4N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C5H4N2O
To a 500 mL round bottom flask were added 150 g of a 3.4 wt% solution of 5- pyrimidinecarboxaldehyde in methanol (5.1 g, 0.047 mole contained 5-pyrimidine carboxaldehyde) and 20.9 g of a 28.2 wt% solution of sodium bisulfite in water (5.9 g, 0.057 mol contained sodium bisulfite). The resulting solution was then stirred for 30 min at ambient temperature. Most of the methanol was distilled off using a rotary evaporator at 50 C to give a light slurry, to which 40 mL of isopropyl alcohol was added. The resulting slurry was cooled down to ambient temperature and stirred overnight after which time the product was collected by filtration, washed with 15 mL of mixture of water and isopropyl alcohol (5 and 10 mL), and suction-dried at ambient temperature for 4 hours to give 16.6 g of white solid. Analysis of the product by NMR indicated 61 wt% of 5-pyrimidinecarboxaldehyde – sodium bisulfite adducts (quantitative yield from 5-pyrimidinecarboxaldehyde). ‘ H NMR (500 MHz, DMSO- d6) d 9.04 (s, 1H), 8.78 (s, 2H), 6.48 (b, 1H), 5.09 (d, J = 5.6 Hz, 1H).
With the rapid development of chemical substances, we look forward to future research findings about 10070-92-5.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; DUMAS, Donald J.; HONG, Junbae; (65 pag.)WO2019/173173; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia