Electric Literature of 10320-42-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10320-42-0, name is 2-Chloro-5-nitropyrimidine. A new synthetic method of this compound is introduced below.
At room temperature, 2-chloro-5- nitropyrimidine (118 mg, 1 mmol) and benzimidazole (175.5 mg, 1.1 mmol) were dissolved in 15 ml of acetonitrile and the anhydrous potassium (414 mg, 3mmol) was added and reacted at room temperature overnight. The next day, the reaction solution was poured into water and extracted with ethyl acetate (50 * 2). The organic phase was washed twice with saturated NaCl solution, dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under a reduced pressure to give a yellow-black solid, which was used directly in the next step without purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,10320-42-0, 2-Chloro-5-nitropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Ancureall Pharmaceutical (Shanghai) Co., Ltd.; SI, Jutong; JIANG, Meifeng; (136 pag.)EP3424924; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia