Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 110099-94-0, name is 2-(Methylthio)pyrimidine-5-carboxylic acid. A new synthetic method of this compound is introduced below., Formula: C6H6N2O2S
The N-{5-[(cyclopropylamino) carbollyl]-2-methylphenyl}-2-(methylthio) pyrimidine- 5-carboxamide used as starting material was prepared as follows:- To a solution of2- (methylthio) pyrimidine-5-carboxylic acid (1. 50g, 8.82 mmol) and 3-amino-N-cyclopropyl-4-methylbenzamide (1. 6Sg, 8.82 mmol) in DMF (7.5 mL) was added HATU (3.69 g, 9.70 mmol) and DIPEA (4. 30 mL, 26.46 mmol) and the resulting mixture stirred for 16 h at room temperature. Saturated aqueous sodium bicarbonate was added and the mixture extracted with ethyl acetate, washed with brine and concentrated under reduced pressure to give the title compound as a solid (3.04 g, 100%); NMR Spectrum: (DMSOdo) 0.57 (m, 2H), 0.69 (m, 2H), 2. 28 (s, 3H), 2.60 (s, 3H), 2.86 (m, 1H), 7.36 (m, 1H), 7.65 (m, 1H), 7.85 (m, 1H), 8.39 (m, 1H), 9.12 (s, 2H), 10. 18 (m, 1H) ; Mass Spectrum : M-H-341.
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Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/61465; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia