Reference of 115581-36-7 ,Some common heterocyclic compound, 115581-36-7, molecular formula is C5H5ClN2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 80 mg (0.50 mmol) of 2-chloro-5-methylthiopyrimidine, which was prepared by a method similar to that of Reference Example 36, in 2.5 ml of dichloromethane, 264 mg (1.0 mmol) of 3-chloro-perbenzoic acid (purity: 65%) was added, and the reaction solution was stirred at room temperature for 90 minutes. After completion of the reaction, saturated sodium hydrogencarbonate aqueous solution was added to the reaction solution and the reaction solution was extracted with dichloromethane. The organic layer was washed with 1.5 mol/L sodium sulfite aqueous solution and dried with anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. The obtained residue was subjected to silica gel column chromatography [n-hexane/ethyl acetate=70/30-40/60 (V/V)] and the fraction including the desired compound was concentrated under reduced pressure to provide 80 mg of the title compound as a white solid (yield: 82%). 1H-NMR spectrum (500 MHz, CDCl3) delta ppm: 9.11 (2H, s), 3.19 (3H, s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 115581-36-7, 2-Chloro-5-(methylthio)pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UBE INDUSTRIES, LTD.; DAIICHI SANKYO COMPANY, LIMITED; Nakamura, Tsuyoshi; Namiki, Hidenori; Terasaka, Naoki; Shima, Akiko; Hagihara, Masahiko; Iwase, Noriaki; Takata, Katsunori; Kikuchi, Osamu; Tsuboike, Kazunari; Setoguchi, Hiroyuki; Yoneda, Kenji; Sunamoto, Hidetoshi; Ito, Koji; US2013/109653; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia