1193-24-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1193-24-4, name is 4,6-Dihydroxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
In a four-necked flask equipped with a reflux condenser, the temperature was raised and stirred, and 228 g of 4,6-dihydroxypyrimidine was added by a constant pressure dropping funnel, the content was 98%,and the content of 633 g of phosphorus oxychloride was 97%.The temperature was raised to 40 to 45 C, and the content of 408 g of triethylamine was added dropwise with content of 99%, after the addition was completed, the temperature was raised to 100 to 105 C and kept for 2 hours. HPLC (high performance liquid phase) analysis of 4,6-dihydroxypyrimidine was less than 0.2%, and the reaction was completed. 880g of toluene was added and cooled tom 0~5 C, 800g of ice water mixture was added, the ice was decomposed to room temperature, the organic phase was decomposed and the aqueous layer was extracted (200 ml of toluene), the organic phase was combined and washed with alkaline water until neutral. Toluene was concentrated. 697 g of toluene dichloropyrimidine solution was obtained, and the purity of 4, 6-dichloropyrimidine was 97.3%, and the content was 39.91%. The crude yield was 92%. The 697 g crude solution was divided into three 240 g, 240 g, 217 g, respectively, as 1, 2, 3, to do the distillation experiment: The temperature of the top of the steam packed tower is required to reach 94 C ~ 96 C, when the temperature was reached, the concentrated organic phase was added dropwise, the feed rate was controlled, the balance was adjusted to prevent the stripper tower from cooling; The obtained organic phase, the quality of the aqueous phase and the purity and concentration of 4,6-dichloropyrimidine are shown in Table 1, the obtained organic phase was concentrated, cooled, crystallized, centrifuged or filtered to obtain a high purity product. The refined yield was as high as 98% or more, and the appearance was white crystal. The experimental results are shown in Table 1.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1193-24-4, 4,6-Dihydroxypyrimidine.
Reference:
Patent; Yueyang Zhenghao Chemical Technology Co., Ltd.; Huang Zhengliang; Li Guang; Yang Xiaoping; Wan Xing; Li Weiping; Li Xiping; Zhang Songbo; Fang Xiaolan; (7 pag.)CN108395409; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia