As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1224944-77-7, name is Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate, molecular formula is C9H8ClN3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C9H8ClN3O2
Step 4. To crude mixture 4-4 in ethanol (1.07mL), A-1-6A (48.47 mg, 0.2148 mmol) was added. The mixture was stirred at 80 C for 2 hours. Water (5mL) was added and extracted with DCM (3 x 5mL). The combined organic phase was washed with brine and then dried over Na2S04. Flash column chromatography (ISCO system, 12g, 0-40% ethyl acetate in hexanes) provided 4-5A (19 mgs, 14.84 % yield), and 4-5B (10.5 mg, 8.2 % yield).
With the rapid development of chemical substances, we look forward to future research findings about 1224944-77-7.
Reference:
Patent; TP THERAPEUTICS, INC.; CUI, Jingrong Jean; LI, Yishan; ROGERS, Evan W.; ZHAI, Dayong; UNG, Jane; (108 pag.)WO2018/22911; (2018); A1;,
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