130049-82-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 130049-82-0, name is 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one. This compound has unique chemical properties. The synthetic route is as follows.
In a flask there were mixed 1.00 g (3.89 mmole) of 6-fluoro-3-(4-piperidinyl)-l,2- benzisoxazole hydrochloride and 0.95 g (3.89 mmole) of 3-(2-chloroethyl)-9- hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-rhoyrido[l,2-a]rhoyrimidin-4-one, 0.83 g (7.79 mmole) of sodium carbonate and 10 ml of ionic solvent l-ethyl-3-methyl-imidazolium ethylsulfate. The suspension was heated to 80 0C or 90 0C and left stirring at this temperature overnight. HPLC showed that the conversion was 88%.It was cooled to room temperature and co-solvent (water and dichloromethane, acetone, ethanol, methanol, water) was added for precipitation of the product, it was filtered and rinsed with this solvent, well sucked off.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130049-82-0, 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one.
Reference:
Patent; KRKA, D.D., NOVO MESTO; RUZIC, Milo?; PRUDIC, Darja; PECAVAR, Anica; SMRKOLJ, Matej; WO2010/14047; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia