With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13040-89-6, name is 5-Chloro-6-methylpyrimidin-4-amine, molecular formula is C5H6ClN3, molecular weight is 143.57, as common compound, the synthetic route is as follows.Product Details of 13040-89-6
To a solution of 1,1-dimethylethyl (25)-2-(3-bromo-2-oxopropyl)-l-piperidinecarboxylate D2 (0.10 g, 0.31 mmol) in DMF (1.50 ml) was added 5-chloro-6-methyl-4-pyrimidinamine (available from Chemstep No.19785) (0.049 g, 0.34 mmol) and the reaction mixture was stirred at 80 0C for 4 h. The solvent was removed under reduced pressure and the residue was taken-up in Et2O. The organic phase was washed with water, dried (Na2SO4), filtered and evaporated under reduced pressure. The residue was eluted through a SCX column to afford a crude material (0.021 g) containing the title compound D7, the corresponding N- Boc protected derivative and some residual 5-chloro-6-methyl-4-pyrimidinamine. [N-Boc derivative data. UPLC: rt = 0.71 min, peaks observed: 365 (M+l, 100%) and 367 (M+l, 33%). C18H25ClN4O2 requires 364]. The crude was dissolved in DCM (1 ml) and TFA (2 ml) was added dropwise. The reaction was left under stirring for 1 h at room temperature. Volatiles were removed under reduced pressure and the residue eluted through a SCX column (500 mg) to afford the title compound D7 (0.018 g)contaminated with some residual 5-chloro-6-methyl-4-pyrimidinamine. UPLC: rt = 0.40 min, peaks observed: 265 (M+l, 100%) and 267 (M+l, 33%). C13Hi7ClN4 requires 264.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13040-89-6, 5-Chloro-6-methylpyrimidin-4-amine, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; WO2009/3997; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia