Adding a certain compound to certain chemical reactions, such as: 145783-15-9, 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 145783-15-9, blongs to pyrimidines compound. category: pyrimidines
(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (R)-mandelate (Compound II, 3.31 g, 10 mmol) and4,6-Dichloro-2-(propylthio)-5-aminopyrimidine (Compound I, 2 g, 13 mmol) was placed in a 50 mL three-necked flask, and ethylene glycol (10 mL) and triethylamine (4.24 g, 42 mmol) were added. ). The reaction mixture was heated to 100 C and stirred for 7 hours. Turn off the heat and naturally cool to 40 C. Isopropyl acetate (10 mL) and water (10 mL) were added and stirred for 1 hour. Stirring was stopped, cooled to room temperature, and allowed to stand for liquid separation. The organic phase was separated, washed with water (10 mL) and dried The mixture was filtered with suction, and the residue was purified by silica gel column chromatography (200-300 mesh chromatography, eluent 0-50% ethyl acetate / petroleum ether) to give compound III (2.6 g, 68 %), light gray solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145783-15-9, its application will become more common.
Reference:
Patent; Yangzijiang Pharmaceutical Group Co., Ltd.; Miao Shifeng; Xu Haoyu; Cai Wei; Zhang Haibo; Lv Huimin; Sun Chunyan; Mu Cong; Wang Deguo; Liu Jinglong; Liu Jing; Hu Tao; (11 pag.)CN109553622; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia