Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 147118-37-4, name is N-(4-(4-Fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide. A new synthetic method of this compound is introduced below., 147118-37-4
EXAMPLES Preparation of rosuvastatin (+)- (3R, 5S)-7- [4- (4-FLUOROPHENYL)-6-ISOPROPYL-2- (N-METHYL-N-METHANESULFONYLAMINO) PYRIMIDIN-5-YL]-3, 5-DIHYDROXY-6 (E) -heptenoic acid calcium salt (2: 1). EXAMPLE 1 Step A Preparation of condensed product N- [5- [- (TERT-BUTYL-DIMETHYL-SILANYLOXY)-6- CYANO-3-OXO-HEX-1-ENYL]-4- (4-FLUOROPHENYL)-6-ISOPROPYL-PYRIMIDIN-2-YL]-N- METHYL-METHANESULFONAMIDE (Condensed product, Formula IV) To a solution of pyrimidine aldehyde (1. 0GM) of Formula III in toluene (20MOI), 1-cyano (2S)-2-[(TERT-BUTYIDIMETHYLSILYL) OXY]-5-OXO-6-TRIPHENYLPHOSPHANYLIDENE hexanenitrile of formula 11 was added and the reaction mixture was REFLUXED for about 24 hours. The reaction mixture was concentrated and the residue titurated with cyclohexane (50ML). The cyclohexane layer was concentrated to give a residue which was purified by silica gel chromatography, eluted with toluene to obtain 1.60gm of the condensed product as a thick oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,147118-37-4, N-(4-(4-Fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide, and friends who are interested can also refer to it.
Reference:
Patent; RANBAXY LABORATORIES LIMITED; WO2004/52867; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia