Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 147118-39-6, name is 5-Oxorosuvastatin methyl ester. A new synthetic method of this compound is introduced below., Recommanded Product: 147118-39-6
S3: Under nitrogen protection, 110 g of tetrahydrofuran and 27.5 g of methanol were added to the reaction flask, the temperature was lowered to -80 ± 5 ° C, 3.19 g of sodium borohydride was added, and the mixture was stirred for 15 minutes, and the temperature was controlled to -80 ± 5 ° C, and 49.5 g was added dropwise. The solution of percentEt2BOMe in tetrahydrofuran was diluted for 1 h. After the end of the incubation, 15.84 g of the S2 product in tetrahydrofuran solution was added dropwise, and the dropping temperature was controlled to -80 ± 5 ° C. After 4 h, the temperature was raised to 4.5 h and the temperature was raised to 20-25 ° C, then adjusted with glacial acetic acid PH = 6.0-7.0, stirred for 30 minutes, re-test PH = 6.0-7.0 qualified, concentrated to dryness under reduced pressure, the end of concentration, then add ethyl acetate and water to stir and dissolve The mixture was allowed to stand for stratification, and the water layer was discarded. The organic layer was washed once with saturated brine, and the organic layer was collected. The organic layer was concentrated at 45 ° C to give an oil (3R, 5S)-7-[4-(4-fluorobenzene) Methyl-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3,5-dihydroxy-6(E)-heptenoic acid methyl ester 15.8 g ;
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Reference:
Patent; Suzhou Zhonglian Chemical Pharmaceutical Co., Ltd.; Hu Liyong; Liu Yaowu; Huang Junhao; Zhang Bo; Zhou Zijin; (10 pag.)CN108586358; (2018); A;,
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