Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 149849-92-3, name is 2-Chloropyrimidine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C5H3ClN2O2
A mixture of 2-chloropyrimidine-4-carboxylic acid (200 mg), aniline (0.115 mL), 6 M hydrochloric acid (0.053 mL) and dimethyl sulfoxide (2.0 mL) was stirred at 80C overnight. The reaction mixture was cooled to room temperature, water was added, and the precipitated solid was collected by filtration. The solid was washed with water to give the title compound (112.1 mg). 1H NMR (300 MHz, DMSO-d6) delta 6.93-7.00 (1H, m), 7.25-7.33 (3H, m), 7.80-7.86 (2H, m), 8.70 (1H, d, J = 5.1 Hz), 9.96 (1H, s), 13.54-13.82 (1H, m).
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Reference:
Patent; Takeda Pharmaceutical Company Limited; SETO, Masaki; BANNO, Yoshihiro; IMAEDA, Toshihiro; KAJITA, Yuichi; ASHIZAWA, Tomoko; KAWASAKI, Masanori; NAKAMURA, Shinji; MIKAMI, Satoshi; NOMURA, Izumi; TANIGUCHI, Takahiko; MARUI, Shogo; (153 pag.)EP3061754; (2016); A1;,
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