The origin of a common compound about 1514-96-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1514-96-1, 4-Chloro-2-(trifluoromethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Related Products of 1514-96-1 ,Some common heterocyclic compound, 1514-96-1, molecular formula is C5H2ClF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 4-chloro-2-(trifluoromethyl)pyrimidine (0.01 g, 0.055 mmol), (S)-tert-buty (2,4-dimethyl-l-(2-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)phenoxy)pentan-2-yl)carbamate (prepared as described in Example 367, Part A) (0.029 g, 0.066 mmol), and KBr (6.52 mg, 0.055 mmol) in 1,4-dioxane (1 mL) was purged with nitrogen fori 5 min. PdCl2(dppf)-CH2Cl2 adduct (4.47 mg, 5.48 muetaiotaomicron) was added, purged for a further 5 min then the reaction mixture was stirred at 80 C microwave for 1.3 h. The reaction mixture was cooled to room temperature and diluted with THF (20 mL) and filtered through diatomaceous earth (Celite). The bed was washed with excess of THF. Filtrate was concentrated under reduced pressure. The crude product was purified via silica gel chromatography (30-40% of ethyl acetate in pet ether) to afford (S)-tert-buty (2,4-dimethyl-l-(2-methyl-4-(2- (trifluoromethyl)pyrirnidin-4-yl)phenoxy)pentan-2-yl)carbamate (0.015 g, 0.024 mmol, 44% yield) as a pale yellow oil. LCMS (ESI) m/e 468.3 [(M+H) +, calcd for C24H33F3N3O3, 468.24]; LC/MS retention time (method B); t& = 1.29 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1514-96-1, 4-Chloro-2-(trifluoromethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BRONSON, Joanne J.; CHEN, Ling; DITTA, Jonathan L.; DZIERBA, Carolyn Diane; JALAGAM, Prasada Rao; LUO, Guanglin; MACOR, John E.; MAISHAL, Tarun Kumar; NARA, Susheel Jethanand; RAJAMANI, Ramkumar; SISTLA, Ramesh Kumar; THANGAVEL, Soodamani; (485 pag.)WO2017/59085; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia