Related Products of 175791-49-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 175791-49-8, name is 5-Bromo-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H4BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Description 2; Ethyl (5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate (D2)5-Bromo-7H-pyrrolo[2,3-d]pyrimidine (D1 , 123 mg, 0.621 mmol) was dissolved in tetrahydrofuran (3 ml_), cooled in an ice bath and treated with sodium hydride (60% by weight, 27.3 mg, 0.683 mmol) portionwise under argon. The resulting mixture was stirred for 15 minutes, allowed to warm to room temperature and stirred for 45 minutes. Ethyl bromoacetate (0.069 ml_, 0.621 mmol) was added and the resulting mixture was stirred for 30 minutes. The solvent was removed under reduced pressure. The residue taken up in water, neutralised using saturated ammonium chloride and extracted with ethyl acetate (x 3). The ethyl acetate layers were
According to the analysis of related databases, 175791-49-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; WO2009/80682; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia