Reference of 1197953-49-3, Adding some certain compound to certain chemical reactions, such as: 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide,molecular formula is C12H12Cl2N3OP, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1197953-49-3.
To a solution of tert-butyl-9- (4-amino-3-methoxyphenyl) -3,9-diazaspiro [5.5] undecane-3-carboxylate(80 mg, 0.213 mmol) Tert-butanol (3.0 mL) was added a solution of (2 – ((2,5-dichloropyrimidin-4-yl) amino) phenyl)dimethylphosphine oxide (67 mg, 0.213 mmol) and methanesulfonic acid (119 mg, 1.07 mmol).The reaction solution wasthen heated to 90 C undernitrogenfor 16 hours.The reaction mixture was concentrated and subjected to preparative separation to give the title compound as a yellow solid(25 mg, yield 21%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Qilu Pharmaceutical Co., Ltd.; Ding Zhaozhong; Chen Shuhui; Liu Xile; Wan Haiwen; Zhang Lu; (27 pag.)CN106928275; (2017); A;,
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