In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Amino-6-hydroxypyrimidin-4(3H)-one
Intermediate 292-Amino-4,6-dichloropyrimidine-5-carbaldehvdePhosphorus oxychloride (93 mL, 1020.54 mmol) was cooled to 50C using an ice bath. Dry DMF (35 mL) was added slowly with stirring over 30 min to the phosphorus oxychloride. A white precipitate formed during the addition. The reaction mixture was gently warmed (450C) to dissolve the precipitate and produce a clear solution to which was added 2- aminopyrimidine-4,6-diol (24.2 g, 190.40 mmol) in small portions over 1 h, then the mixture was heated at 8O0C. The reaction mixture turned a dark red-brown color. After 12 hours, the reaction mixture was cooled to room temperature and excess POCl^ was removed by rotary evaporation. The oily residue was poured over ice. The mixture became homogeneous and was allowed to stir at room temperature overnight to hydrolyze the Vilsmeier adduct. A yellow solid precipitated from solution and was collected by filtration, washed with water and dried under vacuum. The solid precipitate was recrystallized from hot EtOAc. Isolation gave27.7 grams of the title compound. Reference: Bell, L., et ah, J. Heterocyclic Cheni., 1983,20, 41.LC/MS (ES+)[(M+H)+]: 192, 194 for C5H3ClN3O. 1H NMR (300 MHz, d6-DMSO): 8.51 (s,2H), 10.06 (s, IH).
The synthetic route of 56-09-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/27732; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
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