Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4595-60-2, name is 2-Bromopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Bromopyrimidine
General procedure: A Schlenk flask was charged with the catalyst, NaOt-Buand aryl halide, if solid, and the flask was evacuated and backfilled with nitrogen three times. Subsequently, a solution of the aryl halide, if liquid, and the amine in toluene was added. The resulting reaction mixture was stirred under nitrogen at the indicated temperature and time (see Tables incommunication). The crude mixture was absorbed onto silica gel (Merck Silica Gel 60 (0.040-0.063 mm)) and purified by flash column chromatography (MTBE/40-60 petroleum ether eluent).
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Reference:
Patent; Johnson Matthey Public Limited Company; Colacot, Thomas John; Johansson Seechum, Carin; Parisel, Sebastien Laurent; (29 pag.)US10167305; (2019); B2;,
Pyrimidine | C4H4N2 – PubChem,
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