The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Chloro-4-(trifluoromethyl)pyrimidine
2-Chloro-4-(trifluoromethyl)pyrimidine (20 mmol), 2,4-difluorophenylboronic acid (30 mmol), Na2CO3 (36 mmol) andPd(PPh3)4 (0.20 mmol) were dissolved in toluene: ethanol: water(30 mL, 2: 1: 2, v/v). The mixture was refluxed for 24 h andextracted twice with CH2Cl2 at room temperature. The mixedorganic solutionwas washed with brine and the solid obtained waspurified with column chromatography on SiO2 using ethyl acetateand petroleumether (v : v 10 : 1) as eluant to afford white solid 2-(2,4-difluorophenyl)-4-(trifluoromethyl)pyrimidine (dfptfmpm,yield: 75percent). 1H NMR (400 MHz, CDCl3) delta 9.01 (d, J 5.0 Hz, 1H), 8.14(td, J=8.7, 6.6 Hz, 1H), 7.48 (d, J=5.0 Hz, 1H), 6.98-6.83 (m, 2H). 19FNMR (376 MHz, CDCl3) delta 70.12 (s, 3F), 105.06 (d, J=11.0 Hz,1F), 108.14 (d, J=11.0 Hz, 1F). MS (ESI) m/z calcd for C11H5F5N2H[M+H]: 261.05, found: 260.95.
With the rapid development of chemical substances, we look forward to future research findings about 33034-67-2.
Reference:
Article; Zhou, Yong-Hui; Xu, Jing; Wu, Zheng-Guang; Zheng, You-Xuan; Journal of Organometallic Chemistry; vol. 848; (2017); p. 226 – 231;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia