Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. A new synthetic method of this compound is introduced below., HPLC of Formula: C16H11ClN2
A mixture of 2-chloro-4,6-diphenylpyrimidine, 250mg (0.94 mmol), 4- (5-CHLORO-LH-INDOL-3-YL)-4-OXO-BUTYRIC acid 2- trimethylsilanyl-ethyl ester, 380mg (1.03 mmol), K2CO3 260mg (1.87 mmol), and N, N-dimethylaminopyridine, llmg (0.09 mmol) in 20mL DMSO was heated to 80 C for 6h. The mixture was cooled to room temperature and diluted with LOOML of EtOAc. The mixture was washed with sat. aq. LiCl (3XLOOML), water (3XLOOML), sat. aq. NACL (LXLOOML), and dried (MGS04). After the solution was concentrated, the residue was purified via column chromatography (eluted with 10% EtOAc-heptane) to afford the desired product in 0.47g (88%) as a pale yellow SOLID. 1H NMR (DMSO-d6) : 6 9.39 (s, 1H), 8.87 (d, 1H, J = 9.7Hz), 8.56 (s, 1H), 8.51-8. 48 (m, 3H), 8.26 (d, 1H, J = 2.7Hz), 7.64-7. 62 (m, 5H), 7.52 (dd, 1H, 9.7, 2.7Hz), 4.10 (dd, 2H, J = 9.0, 9. OHZ), 3.40 (t, 2H, J = 7.2Hz), 2.67 (t, 2H, J = 7.2Hz), 0.94 (dd, 2H, J = 9.0, 9. 0HZ), 0.00 (s, 9H).
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Reference:
Patent; THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC; WO2004/99159; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia