Reference of 111196-81-7, Adding some certain compound to certain chemical reactions, such as: 111196-81-7, name is 2-Chloro-5-ethylpyrimidine,molecular formula is C6H7ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 111196-81-7.
To a reaction flask was added compound18(700 mg, 2.19 mmol) and 2-chloro-5-ethylpyrimidine (621 mg, 4.37 mmol) in one-portion in the presence of anhydrous DMF. After stirring at room temperature for 5 min, to the resulting clear solution was added anhydrous K2CO3(453 mg, 3.28 mmol) in one-portion. The reaction flask immersed in a pre-heated oil-bath (90) and the reaction mixture was stirred at 90for 4 h and cooled to room temperature. To the reaction mixture at room temperature under vigorous stirring and H2O was added slowly dropwise over 30 min to give an off-white slurry. After the addition was finished, the resulting slurry was stirred at room temperature for additional 10 min. The precipitate was filtered and then rinsed with H2O (2 x 30 mL) and the precipitate was dissolved in EtOAc, and washed with H2O (2 x 30 mL). The organic layer was collected, dried over anhydrous Na2SO4, filtered, concentrated and purifiedby silica gel column chromatography using 40% EtOAc in hexanes to afford compound19(680 mg, 73%).1H-NMR (CDCl3, 300 MHz) delta 9.87 (1H, s, CHO), 8.19 (2H, s, pyrimidine), 7.64 (2H, d,J= 6.9 Hz, Ar), 7.29 (1H, s, thiazole), 7.18 (1H, t,J= 6.9 Hz, Ar), 5.32 (2H, s, OCH2), 4.81 (2H, d,J= 6.0 Hz, CH2), 3.33 (1H, t,J= 12.3 Hz, CH), 3.25 (2H, t,J= 9.3 Hz, CH2), 2.46 (2H, q,J= 9.3 Hz, CH2), 2.19 (2H, d,J= 11.7 Hz, CH2), 1.79 (2H, dq,J= 12.0 Hz, 2.7 Hz, CH2), 1.22 (3H, t,J= 9.0 Hz, CH3).
According to the analysis of related databases, 111196-81-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kim, Hyojin; Cho, Suk Joon; Yoo, Minjin; Kang, Seung Kyu; Kim, Kwang Rok; Lee, Hwan Hee; Song, Jin Sook; Rhee, Sang Dal; Jung, Won Hoon; Ahn, Jin Hee; Jung, Jae-Kyung; Jung, Kwan-Young; Bioorganic and Medicinal Chemistry Letters; vol. 27; 23; (2017); p. 5213 – 5220;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia