The origin of a common compound about 2-Chloro-5-methoxypyrimidine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,22536-65-8, 2-Chloro-5-methoxypyrimidine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.22536-65-8, name is 2-Chloro-5-methoxypyrimidine, molecular formula is C5H5ClN2O, molecular weight is 144.56, as common compound, the synthetic route is as follows.Recommanded Product: 2-Chloro-5-methoxypyrimidine

General procedure: 0.69 g (3.59 mmol) 5-bromo-2-chloro-pyrimidine and 0.70 g (2.99 mmol) of the amine Xlll.1 are added to 10 mL DMSO and 0.78 mL (4.49 mmol) DIPEA. The mixture is stirred at 35° C over night and afterwards purified by HPLC (MeOH/H20/NH3).C17H19BrN4O2 (M= 391 .3 g/mol)ESI-MS: 391/393 [M+H]+Rt (HPLC): 1 .80 min (method A) The following compounds are prepared analogously to example 3.1 : For the example 3.2 the reaction mixture is stirred for 4 d at 45° C

At the same time, in my other blogs, there are other synthetic methods of this type of compound,22536-65-8, 2-Chloro-5-methoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; ROTH, Gerald Juergen; NOSSE, Bernd; HEINE, Niklas; WO2013/92616; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia