As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14394-70-8, name is 2-Chloro-5-methylpyrimidin-4-amine, molecular formula is C5H6ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C5H6ClN3
a) 5-Methyl-2-(2,2,2-trifluoro-ethoxy)-pyrimidin-4-ylamine; Sodium (69 mg, 2 mmol) was added under an atmosphere of nitrogen at room temperature to 2,2,2-trifluoroethanol (3 mL, 40 mmol). The reaction was stirred for 1 hour. To this colorless solution 4-amino-2-chloro-5-methylpyrimidine (287.2 mg, 2.0 mmol) was added and the reaction was heated to 90 C. over night. Water was added and the reaction was extracted twice with ethyl acetate. The combined organic layer was washed with water and with saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered and the solvent was evaporated under reduced pressure to yield the title compound as a white solid (414 mg, 100%).MS ISP (m/e): 208.2 (100) [(M+H)+].1H NMR (DMSO-D6, 300 MHz): delta (ppm)=7.74 (s, 1H), 7.92 (br s, 2H), 4.84 (q, 2H), 1.92 (s, 3H).
With the rapid development of chemical substances, we look forward to future research findings about 14394-70-8.
Reference:
Patent; Baumann, Karlheinz; Goetschi, Erwin; Green, Luke; Jolidon, Synese; Knust, Henner; Limberg, Anja; Luebbers, Thomas; Thomas, Andrew; US2011/190269; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia