Adding a certain compound to certain chemical reactions, such as: 890094-38-9, 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 890094-38-9, blongs to pyrimidines compound. Product Details of 890094-38-9
4-amino-3-methoxy-N-(4-methylpiperazin-1-yl)benzamide(5.3g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 4.5 hours, cooled to room temperature, filtered, washed and dried to obtain a yellow solid(6.8g) in a yield of 77.1%. 1H NMR(400 MHz, DMSO-d6): delta 9.13(s, 1H), 8.38(d, J=6.8Hz, 1H), 7.93(m, 1H), 7.63(d, J=8.0Hz, 1H), 7.46(m, 1H), 7.08(m, 1H), 7.01(m, 1H), 4.31(m, 1H), 3.86(s, 3H), 3.55(br,4H), 2.52(br, 4H), 2.32(s, 3H), 1.24(d, J=6.4Hz, 6H)ppm.
The synthetic route of 890094-38-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
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