Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 34415-10-6, name is 2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid
Step 1: 6-chloro-2-methyl-pyrimidine-4-carboxylic acid chloride; 2.00 g (13.0 mmol) 6-hydroxy-2-methylpyrimidin-4-carboxylic acid were refluxed for 2 h with 11.9 mL (130 mmol) phosphorus oxychloride. After cooling to RT, 2.70 g (13.0 mmol) phosphorus-(V)-chloride were added and the mixture was boiled for 2 h. The reaction mixture was cooled to RT cooled, evaporated to dryness i.vac. And co-evaporated twice with toluene. The residue was triturated several times with DCM and the excess DCM was decanted off. The combined DCM phases were evaporated down and the residue was further reacted as the crude product.Yield: 2.48 g (quantitative)
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Reference:
Patent; Boehringer Ingelheim International GmbH; US2011/172218; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia