Reference of 739364-95-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.739364-95-5, name is 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid, molecular formula is C8H7N3O2, molecular weight is 177.16, as common compound, the synthetic route is as follows.
DPPA (0.5 mL, 2.31 mmol) and Et3N (1.2 mL, 8.3 mmol) were added at rt to a stirred solution of l-4b (300 mg, 1.69 mmol) in 1,4-dioxane (10 mL). The resulting reaction mixture was stirred at rt for 50 min, then l-3b (500 mg, 2.57 mmol) was added and the reaction mixture was stirred at 100 C for 2 h. When TLC indicated consumption of starting material the reaction mixture was cooled to rt, diluted in water (50 mL) and extracted with EtOAc (2 x 100 mL). The combined organic layers were washed with brine (50 mL), dried (Na2S04), filtered and concentrated. The crude material was purified by CombiFlash (silica gel) eluted with 8% MeOH in DCM. Fractions containing compound were combined and concentrated and the resulting solid was triturated in MeCN (2 x 5 mL) followed by trituration in EtOH (15 mL). and dried which gave the title compound (100 mg, 15%) as a solid. LCMS (ES+) m/z 369.20 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis 739364-95-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; MEDIVIR AKTIEBOLAG; ERSMARK, Karolina; KARLSTROeM, Sofia; KLASSON, Bjoern; LUNDGREN, Stina; ROSENQUIST, Asa; SALVADOR ODEN, Lourdes; (155 pag.)WO2018/226150; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia