Synthetic Route of 875251-47-1 , The common heterocyclic compound, 875251-47-1, name is 2-(Pyrimidin-5-yl)ethanol, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
25 g of 5-pyrimidine ethanol (0.20 mol) was added to 500 mL of dichloromethane,83.7 g of thionyl bromide(0.40 mol) was added at 0 C.After reacting at 0 C for about 3 hours, the reaction was detected by TLC and added to ice water. The reaction solution was made alkaline with sodium bicarbonate and extracted three times with dichloromethane. The organic phase was backwashed once with saturated brine.Add anhydrous sodium sulfate to dry, and distill off the solvent under reduced pressure.36 g of 5- (2-bromoethyl) pyrimidine were obtained. The yield was 95% and the purity was 99%.The NMR spectrum of the compound 5- (2-bromoethyl) pyrimidine is shown in Fig. 3
The synthetic route of 875251-47-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Bide Pharmaceutical Technology Co., Ltd.; Yu Guochun; Mi Taoran; (8 pag.)CN110563655; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia