Adding a certain compound to certain chemical reactions, such as: 42839-09-8, 2-Pyrimidinemethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 42839-09-8, blongs to pyrimidines compound. Product Details of 42839-09-8
(2R*, 4S*)-4-{[3, 5-Bis (trifluoromethyl) benzyl]- (5-hydroxypyrimidin-2- yl)} amino-2-ethyl-6-methoxy-3, 4-dihydro-2H- [1, 5] naphthyridine-1- carboxylic acid ethyl ester (150 mg) is dissolved in tetrahydrofuran (1 ml), then thereto are added pyrimidin-2-ylmethanol (41 mg) and triphenylphosphine (98 mg). After adding dropwise 40 % diethyl azodicarboxylate-toluene solution (163, ut) under ice-cooling, the mixture is stirred at room temperature for 1 hour and 30 minutes. Water is added to the reaction mixture and the mixture is extracted with ethyl acetate. The organic layer is washed with a saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The resulting residue is purified by column chromatography (silica gel; hexane: ethyl acetate = 2: 1) to give (2R*, 4S*)-4- { [3, 5-bis (trifluoromethyl) benzyl]- [5- (pyrimidin-2- ylmethoxy) pyrimidin-2-yl]} amino-2-ethyl-6-methoxy-3, 4-dihydro-2H- [1, 5] naphthyridine-l-carboxylic acid ethyl ester (118 mg). MS (m/z): 692 [M+H] +
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,42839-09-8, its application will become more common.
Reference:
Patent; TANABE SEIYAKU CO., LTD.; WO2005/95395; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia