Synthetic Route of 209959-33-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 209959-33-1, name is 2-[Bis(tert-Butoxycarbonyl)amino]-5-bromopyrimidine. A new synthetic method of this compound is introduced below.
3- (2-bis-tert-Butoxycarbonylamino-pyrimidin-5-yl)-acrylic acid tert-butyl ester:; A mixture of (5-bromo-pyrimidin-2-yl) -bis-carbamic acid tert-butyl ester (5.0 g, 13.4 mmol), tert- butylacrylate (3.9 mL, 26.7 mmol), potassium acetate (3.9 g, 40.2 mmol), tetrabutylammonium bromide (4.3g, 13.4 mmol), palladium acetate (150 mg, 0.7 mmol), and N-N’-dimethylformamide (50 mL) was stirred at 70 C for 1 h. Solvent removed under vacuum, and residue partitioned between ether (200 mL) and water. Organic washed further with water and saturated ammonium chloride then dried over magnesium sulfate. Product isolated as a yellow solid after purification on silica. M+1=422.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,209959-33-1, 2-[Bis(tert-Butoxycarbonyl)amino]-5-bromopyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; AMGEN INC.; WO2005/70932; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia