As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22325-27-5, name is 2-Mercapto-4,6-dimethylpyrimidine, molecular formula is C6H8N2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C6H8N2S
General procedure: The intermediates M1-4 were synthesized according to previously reported methods [8,9]. A solution of thiol (1 mmol) was prepared in 1% aqueous NaOH (5 mL). Then, we added, dropwise, 1 mL of halogenated-methyl flavonoids, M1-4 (1 mmol), in DMF. The mixture was heated to 90 C in an oil bath; alternatively it was sealed, and then irradiated in a Smith Creator microwave at 50-100 W to 90 C. After completion of the reaction, the mixture was diluted with water (40 mL) and the precipitate was filtered. Finally, the precipitate was recrystallized from an appropriate solvent to give the title compounds, 5-8.
With the rapid development of chemical substances, we look forward to future research findings about 22325-27-5.
Reference:
Article; Huang, Wei; Chen, Qiong; Yang, Wen-Chao; Yang, Guang-Fu; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 161 – 170;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia