Reference of 2240-25-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2240-25-7, name is 4-Amino-5-bromopyrimidin-2(1H)-one. A new synthetic method of this compound is introduced below.
To a solution of 9 (1 g, 5.26 mmol) in DMF (10 mL) was added 40%chloroacetaldehyde (1.24 g, 6.32 mmol) at rt. The reaction mixture wasstirred at 100 C for 10 h. The reaction mixture was diluted with H2O(20 mL) and the white precipitate was filtered and washed with water.The solid was then dried under reduced pressure to give the titlecompound (0.73 g, 64.8% yield). 1H NMR (300 MHz, DMSO-d6) delta 11.92(s, 1H), 7.89 (d, J=1.0 Hz, 1H), 7.65 (s, 1H), 7.42 (d, J=1.0 Hz, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2240-25-7, 4-Amino-5-bromopyrimidin-2(1H)-one, and friends who are interested can also refer to it.
Reference:
Article; Yang, Yifei; Chen, Pan; Zhao, Leilei; Zhang, Fangqing; Zhang, Bing; Xu, Changliang; Zhang, Huibin; Zhou, Jinpei; Bioorganic Chemistry; vol. 90; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia